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Abstract #4726

Assessment of liver dysfunction with 1H-MRS and relaxometry in a murine model of cerebral malaria

Teodora-Adriana PERLES-BARBACARU1, Emilie PECCHI1, Yann LE FUR1, Alexandre VINTILA1, Monique BERNARD1, and Angèle VIOLA1

1Centre de Résonance Magnétique Biologique et Médicale UMR CNRS 7339, CNRS-Aix Marseille Université, Marseille, France

Cerebral malaria (CM) is the most lethal complication of Plasmodium infection and may be associated with multiple organ failure. We have investigated liver microstructure and metabolism in a widely-used murine model of CM induced with Plasmodium Berghei ANKA using in vivo anatomical MRI, relaxometry and localized proton spectroscopy at 11.75T. Our results show an increase in liver T2 value with CM progression. This increase is apparently linked to a reduction in tissue water content and to lipid remodeling. These alterations could be related to the clinical degradation occurring at the severe stage of the disease as well as to a direct effect of the parasite on the liver.

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