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Abstract #4727

Validation of gadoxetate dynamic contrast-enhanced MRI to assess liver function in rats with liver fibrosis: comparison with shear wave elastography and indocyanine green test

Jimi Huh1, Su Jung Ham2, Young Chul Cho2, Seul-I Lee2, Jisuk Park2, Chul Woong Woo2, Yoonseok Choi3, Dong-Cheol Woo2, and Kyung Won Kim2

1Radiology, Ulsan University Hospital, Ulsan, Republic of Korea, 2Asan Medical Center, Seoul, Republic of Korea, 3Gangneng Asan Medical Center, Gangneng, Republic of Korea

Non-invasive imaging evaluation of the liver fibrosis and liver function has been gaining emphasis currently. In preclinical trial with animal liver fibrosis model, the gadoxetate DCE-MRI is quite feasible to evaluate histopathologic liver fibrosis and physiologic liver function in a non-invasive and repeatable manner. The best MRI index would be the iAUC-15, which is better than kPa on SWE.

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