Abstract #4736

MRI markers of liver related outcomes

Chris R Bradley¹, Eleanor F Cox^1,2, Martin W James², Guru P Aithal², Neil Guha², and Susan T Francis^1,2

¹Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, ²NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom

We used quantitative MR measures to assess changes in microstructure and haemodynamics in the liver and kidney of 60 patients with compensated cirrhosis (CC), 9 patients with decompensated cirrhosis (DC) and 40 healthy volunteers (HV). Liver T₁ and perfusion was significantly reduced and renal T₁ significantly increased with disease severity. In this prospective study, 1 in 6 CC patients have since had a Liver Related Outcome (LRO). These patients showed significant changes in baseline MR measures suggesting these MR measures in our multi-parametric MRI protocol can be used as a marker of LRO.

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