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Abstract #4737

Transducer-Free Hepatic Magnetic Resonance Elastography using Cardiac Wave Induction at 0.3ms Temporal Resolution

Marian A Troelstra1,2, Alessandro Polcaro1, Omar Darwish1, Jose de Arcos1, Torben Schneider3, Khaled Z Abd-Elmoniem4, Ahmed M Gharib4, Jurgen Runge1,2, and Ralph Sinkus1

1Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, 2Department of Radiology and Nuclear Medicine, Academic Medical Center, Amsterdam, Netherlands, 3Philips Healthcare, Guildford, United Kingdom, 4Biomedical and Metabolic Imaging Branch, The National Institute of Diabetes and Digestive and Kidney Diseases, The National Institutes of Health, Bethesda, MD, United States

Hepatic MRE is a promising non-invasive tool for diagnosing liver fibrosis. To facilitate clinical translation, we developed a method to eliminate the need for mechanical actuators for wave generation. Propagation of the transient cardiac shear waves within the liver caused by cardiac-valve closure can be imaged at a very high temporal resolution (0.3ms) using a 2D motion-sensitised pencil beam, with total data acquisition time fitting into four consecutive breath holds. These images were used to estimate liver stiffness, with a high temporal resolution allowing for reliable fitting to the space-time images and thus robust speed estimates.

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