The evaluation of hepatic iron and fat by MR techniques is of increasing interest for clinical routine. The purpose of our study was to investigate the influence of different multi-peak fat models on the obtained R2*, PDFF and goodness of fit values in patients with suspicion of diffuse liver disease. It is shown that the use of multi-peak fat spectrum modeling is highly recommended for accurate quantification of R2* and PDFF . A 6-peak model resulted in the best goodness of fit. The use of a higher number of peaks seems to offer no additional advantage.