Quantitative T1 mapping is starting to be used clinically as a measure of liver fibrosis, but is confounded by the presence of inflammation in the liver. Work presented here describes the development of a new quantitative MRI measure, “change in perfusion in response to CO2 gas challenge”, in mice. This vasoactive challenge takes advantage of the pathological hallmarks of perivascular collagen seen in fibrosis, which is hypothesised to attenuate increases in tissue perfusion during hypercapnia.
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