Meeting Banner
Abstract #4739

Selective detection of liver fibrosis: Perfusion with hypercapnia challenge rather than T1 mapping.

John J Connell1, Thomas A Roberts1, May Zaw-Thin1, P Stephen Patrick1, Rajiv Ramasawmy1, Daniel J Stuckey1, Manil D Chouhan2, Daniel Antoine3, Jack A Wells1, Mark F Lythgoe1, and Tammy L Kalber1

1Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, 2Centre for Medical Imaging, University College London, London, United Kingdom, 3University of Liverpool, Liverpool, United Kingdom

Quantitative T1 mapping is starting to be used clinically as a measure of liver fibrosis, but is confounded by the presence of inflammation in the liver. Work presented here describes the development of a new quantitative MRI measure, “change in perfusion in response to CO2 gas challenge”, in mice. This vasoactive challenge takes advantage of the pathological hallmarks of perivascular collagen seen in fibrosis, which is hypothesised to attenuate increases in tissue perfusion during hypercapnia.

This abstract and the presentation materials are available to members only; a login is required.

Join Here