Abstract #4739

Selective detection of liver fibrosis: Perfusion with hypercapnia challenge rather than T1 mapping.

John J Connell¹, Thomas A Roberts¹, May Zaw-Thin¹, P Stephen Patrick¹, Rajiv Ramasawmy¹, Daniel J Stuckey¹, Manil D Chouhan², Daniel Antoine³, Jack A Wells¹, Mark F Lythgoe¹, and Tammy L Kalber¹

¹Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, ²Centre for Medical Imaging, University College London, London, United Kingdom, ³University of Liverpool, Liverpool, United Kingdom

Quantitative T1 mapping is starting to be used clinically as a measure of liver fibrosis, but is confounded by the presence of inflammation in the liver. Work presented here describes the development of a new quantitative MRI measure, “change in perfusion in response to CO₂ gas challenge”, in mice. This vasoactive challenge takes advantage of the pathological hallmarks of perivascular collagen seen in fibrosis, which is hypothesised to attenuate increases in tissue perfusion during hypercapnia.

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