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Abstract #4750

Imaging inflammation following MI using hyperpolarized pyruvate and 3D Spectral-Spatial EPI

Jack J J J Miller1,2,3, Andrew J Lewis1,3, Carolyn A Carr3, Oliver Rider1, Stefan Neubauer1, and Damian J Tyler1,3

1Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom, 2Department of Physics, University of Oxford, Oxford, United Kingdom, 3Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom

Current clinical imaging techniques offer only limited assessment of innate immune cell driven inflammation, which is an emerging therapeutic target in myocardial infarction. However, macrophages have a defined metabolic phenotype and are highly glycolytic when activated following injury. Here we show that hyperpolarized [1-$$$^{13}$$$C]pyruvate imaging specifically detects this phenotype, which is altered by pharmacological blockade that modulates monocyte/macrophage inflammatory function both in vitro and in vivo. We conclude that cardiac hyperpolarized [1-$$$^{13}$$$C]lactate several days post insult reflects immunology, and not necessarily ischaemia.

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