Abstract #4749

Non-invasive MR-based blood oximetry via multi-parametric, non-linear estimation: initial multi-center experience in adult and pediatric patients

Juliet Varghese¹, Lajja Desai², Rizwan Ahmad^1,3, Lee C Potter⁴, Ning Jin⁵, Cynthia K Rigsby², Paul Tannous², Aimee K Armstrong⁶, Michael Markl⁷, Kan N Hor⁶, Subha Raman^1,8,9, and Orlando P Simonetti^1,8,9

¹Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, United States, ²Northwestern University School of Medicine, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States, ³Department of Biomedical Engineering, The Ohio State University, Columbus, OH, United States, ⁴Department of Electrical and Computer Engineering, The Ohio State University, Columbus, OH, United States, ⁵Cardiovascular MR R&D, Siemens Medical Solutions USA, Inc, Columbus, OH, United States, ⁶The Heart Center, Nationwide Children's Hospital, Columbus, OH, United States, ⁷Departments of Radiology and Biomedical Engineering, Northwestern University Feinberg School of Medicine, Chicago, IL, United States, ⁸Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH, United States, ⁹Department of Radiology, The Ohio State University, Columbus, OH, United States

Non-invasive estimation of blood oxygen (O2) saturation by magnetic resonance (MR) imaging would be useful in evaluating shunt severity in congenital heart disease, and oxygen delivery and consumption energetics in heart failure and pulmonary hypertension. A T2-based, non-linear, multi-parameter method has been developed to non-invasively determine O2 saturation in the heart and great vessels. In this multi-center study, the feasibility and accuracy of the technique is evaluated against gold-standard catheterization measurements in the cardiac chambers and vessels in a preliminary cohort of adult and pediatric patients with cardiovascular disease.

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