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Abstract #4748

Respiratory motion-corrected simultaneous myocardial viability PET and coronary MR angiography: initial clinical validation

Camila Munoz1, Karl P Kunze2, Radhouene Neji3, Christoph Rischpler2, René M Botnar1, Stephan G Nekolla2, and Claudia Prieto1

1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2Nuclear Medicine, TU Munich, Munich, Germany, 3MR Research Collaborations, Siemens Healthcare, Frimley, United Kingdom

Cardiac PET-MR imaging has shown promising results for the comprehensive assessment of coronary artery disease. Here we present an initial clinical validation of a recently demonstrated respiratory motion-corrected PET-MR framework in patients with chronic total occlusion. Simultaneous visualization of the coronary lumen by Coronary MR Angiography (CMRA) and myocardial viability by 18F-FDG PET was compared against X-ray angiography and LGE-MRI. We demonstrate that the proposed framework produces diagnostic images in both modalities in a short and time-efficient examination of ~12 minutes. Motion correction improved visible length and sharpness of the coronary arteries by CMRA and delineation of the myocardium and noise reduction by 18F-FDG PET, resulting in good agreement with X-ray angiography and LGE-MRI.

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