Cardiac PET-MR imaging has shown promising results for the comprehensive assessment of coronary artery disease. Here we present an initial clinical validation of a recently demonstrated respiratory motion-corrected PET-MR framework in patients with chronic total occlusion. Simultaneous visualization of the coronary lumen by Coronary MR Angiography (CMRA) and myocardial viability by 18F-FDG PET was compared against X-ray angiography and LGE-MRI. We demonstrate that the proposed framework produces diagnostic images in both modalities in a short and time-efficient examination of ~12 minutes. Motion correction improved visible length and sharpness of the coronary arteries by CMRA and delineation of the myocardium and noise reduction by 18F-FDG PET, resulting in good agreement with X-ray angiography and LGE-MRI.
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