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Abstract #4759

Proton magnetic resonance spectroscopy to assess lipid content in cardiac amyloidosis

Mareike Gastl1,2,3, Sophie Peereboom1, Alexander Gotschy1,2, Maximilian Fuetterer1, Constantin von Deuster1, Florian Bönner3, Malte Kelm3, Andreas Flammer2, Robert Manka1,2,4, and Sebastian Kozerke1

1Institue for Biomedical Engineering, ETH Zürich, Zürich, Switzerland, 2Department of Cardiology, University Heart Center, University Hospital Zurich, Zürich, Switzerland, 3Department for Cardiology, Pneumology and Angiology, Heinrich Heine University, Düsseldorf, Düsseldorf, Switzerland, 4Institute of Diagnostic and Interventional Radiology, University Hospital Zürich, Zürich, Switzerland

Amyloidosis is a multisystemic disorder frequently affecting the heart and causing heart failure. In this work, MR imaging and spectroscopy was implemented and applied to characterize myocardial structure and function as well as changes in fatty acid storage of the heart. We found that myocardial triglyceride-to-water ratio was significantly decreased in amyloidosis compared to age-and body mass index-matched controls. Myocardial triglyceride-to-water ratio showed a negative tendency with increasing markers of heart failure. It is concluded that proton spectroscopy may provide an additional biomarker to gauge progression of cardiac amyloidosis.

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