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Abstract #4764

Tracking of PLGA-PFCE-labeled Cardiac Stem Cells Seeded on Novel Biodegradable Poly(3-hydroxyoctanoate) Scaffolds Implanted on the Murine Myocardium using 1H and 19F  MRI/MRS

Chris Constantinides1, Pooja Basnett2, Barbara Lukasiewicz2, Ricardo Carnicer Hijazo1, Mangala Srinivas3, Carolyn Carr1, and Ipsita Roy2

1U. Oxford, Oxford, United Kingdom, 2U. Westminster, London, United Kingdom, 3Radboud University Medical Center, Nijmegen, Netherlands

Controlled administration of cardiac progenitor stem cells (CPCs), and their visualization and tracking and release, still present tremendous challenges in cellular/tissue therapy, yet fundamental and necessary tasks towards a therapeutically successful approach. In this work, we propose the synthesis and use of novel, functional biodegradable, biocompatible, Polyhydroxyalkanoate (PHA) and Poly-caprolactone (PCL) polymer blend scaffolds to: a) achieve controlled delivery of CPCs, thereby prolonging the viability, and maximizing retention of delivered stem cells to the murine myocardium, and b) the use of 19F MRI/MRS to noninvasively detect, and monitor the cells temporally.

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