Controlled administration of cardiac progenitor stem cells (CPCs), and their visualization and tracking and release, still present tremendous challenges in cellular/tissue therapy, yet fundamental and necessary tasks towards a therapeutically successful approach. In this work, we propose the synthesis and use of novel, functional biodegradable, biocompatible, Polyhydroxyalkanoate (PHA) and Poly-caprolactone (PCL) polymer blend scaffolds to: a) achieve controlled delivery of CPCs, thereby prolonging the viability, and maximizing retention of delivered stem cells to the murine myocardium, and b) the use of 19F MRI/MRS to noninvasively detect, and monitor the cells temporally.
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