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Abstract #4765

T1-mapping Cardiac-Manganese Enhanced MRI: Assessment of Calcium Homeostasis and Ischemic Injury in Mice

Nur Hayati Jasmin1,2, Laurence H Jackson3, Thomas A Roberts4, Valerie Taylor1, Mark F Lythgoe1, and Daniel J Stuckey1

1Division of Medicine, UCL Centre for Advanced Biomedical Imaging, London, United Kingdom, 2School of Medical Imaging, Universiti Sultan Zainal Abidin, Terengganu Darul Iman, Malaysia, 3Biomedical Engineering, Kings College London, London, United Kingdom, 4Perinatal Imaging & Health, Kings College London, London, United Kingdom

Intracellular MR contrast agents can provide essential information on cell viability. Manganese (Mn2+) is an efficient intracellular MR contrast agent. As an analogue of Calcium, Mn2+-induced changes in T1 and can be used as an indicator of the rate of Ca2+ influx into cardiomyocytes in vivo and could provide additional information to that routinely acquired using late Gd-enhanced MRI. By preloaded the myocardium with Mn2+ prior to coronary occlusion, we showed that MEMRI T1-mapping allows sensitive in vivo detection of subtle changes and accumulation of Mn2+ in viable myocytes in the early phase of myocardial injury.

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