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Abstract #4798

Reduced cerebral blood flow and oxygen consumption in asymptomatic unilateral carotid stenosis patients assessed by arterial spin labeling and multi-parametric quantitative BOLD imaging

Jens Goettler1,2, Stephan Kaczmarz1,2, Claus Zimmer1, Christian Sorg1, Christine Preibisch1,3, and Fahmeed Hyder2

1Department of Neuroradiology, Technische Universität München, Munich, Germany, 2Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, 3Clinic for Neurology, Technische Universität München, Munich, Germany

Assessing cerebral hemodynamics and oxygen consumption in patients with clinically asymptomatic, high-grade internal carotid artery stenosis is crucial to estimate risk of stroke and cognitive impairment. Here, 23 patients with unilateral high-grade carotid stenosis and 24 age-matched healthy controls underwent a range of MRI scans, including quantitative BOLD, DSC and pCASL imaging to assess relative oxygen extraction (OEF), blood flow (CBF) and oxygen consumption (CMRO2). Both CBF and CMRO2 were reduced on the stenosis side, indicating that the proposed easily applicable MR-protocol is useful to estimate even subtle CBF and CMRO2 changes in carotid stenosis patients.

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