Abstract #4798

Reduced cerebral blood flow and oxygen consumption in asymptomatic unilateral carotid stenosis patients assessed by arterial spin labeling and multi-parametric quantitative BOLD imaging

Jens Goettler^1,2, Stephan Kaczmarz^1,2, Claus Zimmer¹, Christian Sorg¹, Christine Preibisch^1,3, and Fahmeed Hyder²

¹Department of Neuroradiology, Technische Universität München, Munich, Germany, ²Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, ³Clinic for Neurology, Technische Universität München, Munich, Germany

Assessing cerebral hemodynamics and oxygen consumption in patients with clinically asymptomatic, high-grade internal carotid artery stenosis is crucial to estimate risk of stroke and cognitive impairment. Here, 23 patients with unilateral high-grade carotid stenosis and 24 age-matched healthy controls underwent a range of MRI scans, including quantitative BOLD, DSC and pCASL imaging to assess relative oxygen extraction (OEF), blood flow (CBF) and oxygen consumption (CMRO₂). Both CBF and CMRO₂ were reduced on the stenosis side, indicating that the proposed easily applicable MR-protocol is useful to estimate even subtle CBF and CMRO₂ changes in carotid stenosis patients.

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