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Abstract #4806

Myelin imaging may reveal ischemic microstructural damage correlated with neurocognitive dysfunction in patients with moyamoya disease

Shoko Hara1,2, Masaaki Hori2, Yasuaki Tsurushima3, Yoji Tanaka1, Taketoshi Maehara1, Shigeki Aoki2, and Tadashi Nariai1

1Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan, 2Radiology, Juntendo University, Tokyo, Japan, 3Radiology, Kenshinkai Tokyo Medical Clinic, Tokyo, Japan

To investigate myelin structural damage caused by chronic ischemia, we applied myelin imaging using magnetization transfer saturation (MTsat) method to 15 patients with moyamoya disease (36.6±11.6-year-old) and 10 normal volunteers (28.4±5.2-year-old). Although many patients received bypass surgery in the past and currently had good hemodynamic status, we found myelin volume fraction (MVF) was significantly lower and g-ratio was significantly higher in the patient group compared to normal controls. Moreover, regional MVF values showed some correlation with neurocognitive tests. This finding suggests myelin damage occurs in moyamoya disease, is associated with neurocognitive dysfunction, and is perhaps irreversible.

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