Oxygen extraction fraction (OEF) reflects tissue oxygen consumption, which is very useful to predict the outcome of ischemic stroke in metabolic level. In this work, we evaluate a combined quantitative susceptibility mapping (QSM) and quantitative bold oxygen level dependent (qBOLD) method for measuring OEF based on MRI multi echo gradient echo (GRE) imaging in 11 acute ischemic stroke patients. OEF maps displayed various patterns both in the lesion and in the ASL-CBF/DWI mismatch area, consistent with previous PET studies. OEF with a heterogeneous increase within the lesion or in the CBF/DWI mismatch area may represent salvageable ischemic tissue, while OEF decrease may suggest irreversible infarct.
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