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Abstract #4808

Atherosclerotic Diseases in Entire Craniocervical Arteries and Aortic Arch and Stroke Risk: A 3D Multicontrast MR Vessel Wall Imaging Study

Dongye Li1,2, Wei Dai3, Ying Cai4, Yongjun Han1, Guoen Yao3, Huijun Chen2, Chun Yuan5, and Xihai Zhao2

1Centre for Brain Disorders Research, Capital Medical University and Beijing Institute for Brain Disorders, Beijing, China, 2Center for Biomedical Imaging Research, Tsinghua University, Beijing, China, 3Department of neurology, The first affiliated hospital of the PLA general Hospital, Beijing, China, 4Department of Radiology, Taizhou People's Hospital, Taizhou, China, 5Department of Radiology, University of Washington, Seattle, WA, United States

Vulnerable atherosclerotic plaque in intracranial and extracranial carotid arteries and aortic arch is one of major causes of ischemic stroke. This study investigated the characteristics of atherosclerotic plaques in the craniocervical arteries and aortic arch and their relationships with stroke risk using 3D multicontrast MR vessel wall imaging. We found that high risk atherosclerotic plaques were most prevalent in intracranial arteries among three vascular beds. Combination of the maximum wall thickness in intracranial with extracranial carotid arteries might be a stronger predictor for cerebral acute ischemic lesions than that in each vascular bed alone.

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