Abstract #4809

Magnetic Susceptibility Mapping Reveals Altered Vein Oxygenation in Patients with Brain Arteriovenous Malformations: A Preliminary Study

Emma Biondetti¹, Alvaro Rojas Villabona^2,3, Hans Rolf Jäger^4,5, David L Thomas^6,7, and Karin Shmueli¹

¹Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ²The Gamma Knife Centre at Queen Square, National Hospital for Neurology and Neurosurgery, London, United Kingdom, ³Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, United Kingdom, ⁴The Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom, ⁵Academic Neuroradiological Unit, Department of Brain Repair and Rehabilitation, University College London, London, United Kingdom, ⁶Academic Neuroradiological Unit, Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom, ⁷Leonard Wolfson Experimental Neurology Centre, Institute of Neurology, University College London, London, United Kingdom

Arteriovenous malformations (AVMs) are vascular anomalies characterised by arteriovenous shunting with the lack of a capillary bed. Since the veins that drain an AVM contain arterialised blood, they would be expected to have a higher venous oxygen saturation (SvO₂) than normal veins. Due to the paramagnetic properties of deoxyhaemoglobin, SvO₂ can be calculated using magnetic susceptibility mapping (SM). Here, we calculated SM-based SvO₂ in five patients with a brain AVM. We found higher SvO₂ in the AVM draining veins compared to normal veins, showing that SM might be a valuable tool to study AVM physiology.

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