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Abstract #4812

Oxygen Extraction Fraction and R2* Mapping in Cerebrovascular Disease using an Acetazolamide Challenge.

Christopher Leatherday1, Seena Dehkharghani1, Fadi Nahab2, Jason W. Allen1, Junjie Wu1, Ranliang Hu1, and Deqiang Qiu1

1Radiology and Imaging Sciences, Emory University, Atlanta, GA, United States, 2Neurology, Emory University, Atlanta, GA, United States

Increased cerebral oxygen extraction fraction (OEF) in cerebrovascular disease is linked with a greatly elevated risk of recurrent ischemic stroke. The current gold standard for OEF imaging is Oxygen-15 PET; which is less widely available and more expensive than MRI, and includes an ionizing radiation dose. We studied quantitative susceptibility mapping derived OEF maps and R2* mapping combined with an Acetazolamide challenge in a group of unilateral CVD patients, and found increased OEF and reduced cerebrovascular reactivity in the disease-affected hemisphere using these methods. With further refinement, these techniques may provide a clinical alternative to 15O-PET for OEF imaging.

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