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Abstract #4813

Effects of physical exercise on hippocampal volume and vasculature in young adults

Antonia Kaiser1,2,3, Michelle M Solleveld1,2,3, Linda Knutsson4, Matthias JP van Osch5, Liesbeth Reneman1,2, Paul J Lucassen2,3, and Anouk Schrantee1,2,3,6

1Department of Radiology and Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 2Amsterdam Brain and Cognition, University of Amsterdam, Amsterdam, Netherlands, 3Swammerdam Institute for Life Sciences, Center for Neurosciences, University of Amsterdam, Amsterdam, Netherlands, 4Department of Medical Radiation Physics, Lund University, Lund, Sweden, 5C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 6Spinoza Centre for Neuroimaging, Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, Netherlands

The underlying neurobiological changes of exercise-induced hippocampal volume increases are poorly understood, but a substantial role for vascular plasticity, such as perfusion and angiogenesis, has been suggested. We here studied the effect of a high and low intensity exercise intervention on the hippocampal volume and vasculature. Exercise did not induce hippocampal volume changes, despite a baseline association between fitness and volume. Interestingly, improved fitness resulted in increased hippocampal cerebral blood flow (CBF) (p=0.01) and gray matter CBF (p=0.07). No effect on cerebral blood volume was found. This may suggest that perfusion effects are not hippocampus-specific.

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