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Abstract #4814

New vision of tuberous sclerosis complex on 7-Tesla MRI

Kaibao Sun1,2, Jianfei Cui3, Bo Wang1, Tao Jiang4, Zhongwei Chen1, Fei Cong1,2, Yan Zhuo1,2, Rong Xue1,2, Shuli Liang3, and Lin Chen1,2

1State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 2University of Chinese Academy of Sciences, Beijing, China, 3Chinese PLA general hospital, Beijing, China, 4Beijing Tian Tan Hospital, Capital Medical University, Beijing, China

Tuberous sclerosis complex is a multisystem genetic disorder characterized by the growth of numerous tuberous lesions in brain. However, few in vivo studies on TSC have focused on venous structure changes, their association with TSC lesions, and iron accumulation in basal ganglia. 7T susceptibility weighted imaging was performed on eleven TSC patients in comparison with fifteen age- and sex-matched healthy controls. The tubers might develop along penetrating veins. There might be coexistence of iron deposition and calcification in basal ganglia. These in vivo 7T MRI findings provided new perspectives for better understanding the brain pathology in patients with TSC.

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