Abstract #4815

Increased intracellular volume fraction, orientation dispersion and diffusion kurtosis in the brain are associated with poor functional outcome in comatose cardiac arrest patients

Ona Wu¹, Eric S Rosenthal², Brittany B. Mills², Gaston Cudemus-Deseda³, Brian L Edlow², W. Taylor Kimberly², Ming Ming Ning², William A Copen⁴, Pamela W. Schaefer⁴, Joseph T Giacino⁵, and David M Greer⁶

¹Department of Radiology, MGH Athinoula A Martinos Center, Charlestown, MA, United States, ²Department of Neurology, Massachusetts General Hospital, Boston, MA, United States, ³Department of Anesthesiology, Massachusetts General Hospital, Boston, MA, United States, ⁴Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, ⁵Department of Rehabilitation Neuropsychology, Spaulding Rehabilitation Hospital, Charlestown, MA, United States, ⁶Department of Neurology, Boston Medical Center, Boston, MA, United States

Cardiac arrest patients who are comatose after restoration of spontaneous circulation were prospectively studied to determine whether changes to intracellular volume fraction (ICVF), orientation dispersion and diffusion kurtosis imaging (DKI) can be used to discriminate patients likely to recover consciousness. Subjects who failed to wake up had greater median ICVF, and DKI compared to subjects who woke up. Increases in ICVF, and DK are associated with more severe acute ischemic brain injury. Multi-shell diffusion imaging may help identify patients that may recover consciousness.

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