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Abstract #4816

Hemodynamic Biomarkers to Assess Disease Severity in Patients with Intracranial Atherosclerotic Disease using Dual-Venc 4D Flow MRI

Alireza Vali1, Maria Aristova1, Sameer A. Ansari2,3, Ayesha Muzaffar1, Shyam Prabhakaran2, Michael Markl1, and Susanne Schnell1

1Radiology, Northwestern University, Chicago, IL, United States, 2Neurology, Northwestern University, Chicago, IL, United States, 3Neurological Surgery, Northwestern University, Chicago, IL, United States

To conduct a comprehensive assessment of hemodynamics in patients with intracranial atherosclerotic disease (ICAD), an automated analysis tool was developed to quantify 4D flow MRI data, including extraction of pressure gradient and flow resistance across the ICAD stenosis and flow and peak velocity asymmetry indices. For three ICAD cases with identical degree of stenosis, the results demonstrated variability in both flow resistance and flow asymmetry indices. With the inclusion of more patients spanning a spectrum of stenosis degrees, it may be possible to demonstrate the utility of flow resistance as a new metric for characterizing the hemodynamic impacts of ICAD.

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