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Abstract #4818

A comparison of cerebrovascular reactivity at 1.5 and 3T in cerebral small vessel disease patients

Michael S Stringer1,2,3, Gordon W Blair1,2,3, Yulu Shi1,2,3, Iona Hamilton1,2,3, Ian Marshall1,2,3, Fergus Doubal1,2,3, Michael J Thrippleton1,2,3, and Joanna M Wardlaw1,2,3

1Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, 2Edinburgh Dementia Research Centre in the UK Dementia Research Institute, Edinburgh, United Kingdom, 3Fondation Leducq Network for the Study of Perivascular Spaces in Small Vessel Disease, University of Edinburgh, Edinburgh, United Kingdom

Cerebrovascular reactivity can be measured using blood oxygen level dependent (BOLD) MRI and is a potential mechanism in cerebral small vessel disease (SVD). Investigations of the effect of field strength on CVR have been limited, particularly in patient groups. In this study CVR measurements within a series of preselected regions in SVD patients were assessed at 1.5 and 3T. Mean CVR was greater at 3T in 12 of the 14 regions, however differences, as assessed with Bland-Altman plots, were within reasonable limits. These results point to the importance of considering other scanner specific factors beyond field strength when measuring CVR.

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