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Abstract #4835

Brain morphometric changes and functional connectivity alterations in post-stroke fatigue

Milanka Visser1, Thomas Lillicrap1, Carlos Garcia-Esperon1, Bénédicte Maréchal2, Mark Parsons1, Christopher Levi1, and Andrew Bivard1

1Faculty of Health and Medicine, University of Newcastle, Newcastle, Australia, 2Department of Radiology, Lausanne University Hospital, Lausanne, Switzerland

Debilitating fatigue is the most common consequence of stroke, however there are no known clinical or radiological biomarkers associated with post-stroke fatigue. We assessed differences in regional brain volumes obtained from T1-weighted, high-resolution structural scans between stroke survivors with and without severe fatigue. Differences were observed in the volume of the globus pallidus and putamen, as well as the ipsilesional temporal, parietal and frontal lobe. The mentioned morphological differences between stroke survivors with and without severe fatigue have also been reported in multiple sclerosis and Parkinson’s-related fatigue, suggesting a possible common mechanism.

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