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Abstract #4834

Carotid stenosis: a risk factor for white matter disease even at presymptomatic stage

Pedro Henrique Rodrigues da Silva1, Ana Paula Afonso Camargo2, Antonio Carlos Santos Senra Filho3, Luiz Otavio Murta Junior3, Octávio Marques Pontes Neto2, and Renata Ferranti Leoni1

1Department of Physics, FFCLRP, University of São Paulo, Ribeirão Preto, Brazil, 2Department of Neurosciences and Behavioral Science, FMRP, University of São Paulo, Ribeirão Preto, Brazil, 3Department of Computing and Mathematics, FFCLRP, University of São Paulo, Ribeirão Preto, Brazil

Studies have suggested that cerebral white matter hyperintensity (WMH) is due to hypertension and is associated with carotid artery stenosis (CAS). However, it is unclear whether this association is attributable to effects on WM and how asymptomatic CAS contributes to it. Therefore, we aimed to assess the association between ACAS and WMH lesions and its relationship with cognitive decline using MRI to provide information that may help predicting cases at risk of brain ischemia. Our data showed that ACAS is associated with WMH lesions and cognitive decline, indicating that ACAS, in addition to age, is likely to cause WM lesions.

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