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Abstract #4841

Association between Diffusion Weighed Imaging Measured Pretreatment Ischemic Volume and Functional Outcome in Ischemic Stroke

Yu XIE1, Catherine Oppenheim2, Francis Guillemin3, Vincent Gautheron2, Benjamin Gory4, Hélène Raoult5, Sébastien Soize6, Bailiang CHEN7, Jacques Felblinger1,7, Gabriela Hossu7, and Serge Bracard1,8

1IADI, U947, INSERM, Université de Lorraine, CHRU Nancy, Nancy, France, 2Department of Neuroradiology, Sainte-Anne Hospital and Paris-Descartes University, INSERM U894, Paris, France, 3CIC 1433 Epidémiologie Clinique, INSERM, Université de Lorraine, CHRU Nancy, Nancy, France, 4INSERM U1237, “Physiopathology and Imaging for Neurological Disorders (PhIND)”, GIP Cyceron, Caen, France, 5Department of Neuroradiology, University Hospital of Rennes, Rennes, France, 6Department of Neuroradiology, University Hospital of Reims, Reims, France, 7CIC 1433 Innovation Technologique, INSERM, Université de Lorraine, CHRU Nancy, Nancy, France, 8Department of Diagnostic and Interventional Neuroradiology, CHRU Nancy, Nancy, France

The association between pretreatment ischemic volume (PIV) measured on diffusion weighted images (DWI) and functional outcome after mechanical thrombectomy is of great clinical importance but has yet to be determined. We analyzed 298 ischemic stroke patients from the multicentric study THRACE. Our results showed that increased PIV was an independent predictor for a lower probability of functional independence, a less favorable degree of disability, and a higher mortality rate. PIV measured on DWI is a valuable early predictor for functional outcome in ischemic stroke patients, and thus can contribute to patient selection for optimal therapeutic intervention.

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