Abstract #4841

Association between Diffusion Weighed Imaging Measured Pretreatment Ischemic Volume and Functional Outcome in Ischemic Stroke

Yu XIE¹, Catherine Oppenheim², Francis Guillemin³, Vincent Gautheron², Benjamin Gory⁴, Hélène Raoult⁵, Sébastien Soize⁶, Bailiang CHEN⁷, Jacques Felblinger^1,7, Gabriela Hossu⁷, and Serge Bracard^1,8

¹IADI, U947, INSERM, Université de Lorraine, CHRU Nancy, Nancy, France, ²Department of Neuroradiology, Sainte-Anne Hospital and Paris-Descartes University, INSERM U894, Paris, France, ³CIC 1433 Epidémiologie Clinique, INSERM, Université de Lorraine, CHRU Nancy, Nancy, France, ⁴INSERM U1237, “Physiopathology and Imaging for Neurological Disorders (PhIND)”, GIP Cyceron, Caen, France, ⁵Department of Neuroradiology, University Hospital of Rennes, Rennes, France, ⁶Department of Neuroradiology, University Hospital of Reims, Reims, France, ⁷CIC 1433 Innovation Technologique, INSERM, Université de Lorraine, CHRU Nancy, Nancy, France, ⁸Department of Diagnostic and Interventional Neuroradiology, CHRU Nancy, Nancy, France

The association between pretreatment ischemic volume (PIV) measured on diffusion weighted images (DWI) and functional outcome after mechanical thrombectomy is of great clinical importance but has yet to be determined. We analyzed 298 ischemic stroke patients from the multicentric study THRACE. Our results showed that increased PIV was an independent predictor for a lower probability of functional independence, a less favorable degree of disability, and a higher mortality rate. PIV measured on DWI is a valuable early predictor for functional outcome in ischemic stroke patients, and thus can contribute to patient selection for optimal therapeutic intervention.

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