Abstract #4840

Quantitative Cerebral Blood Flow Measured with Arterial Spin Labeling MRI in the Unaffected Contralateral Brain Hemisphere Predicts Outcome in Acute Ischemic Stroke

Thoralf Thamm^1,2, Jia Guo¹, Jarrett Rosenberg¹, Tie Liang¹, Michael P Marks¹, Soren Christensen¹, Huy M Do¹, Stephanie M Kemp¹, Emily A Ryan¹, Tudor G Jovin³, Bart P Keogh⁴, Jenny Chen⁵, Maarten G Lansberg¹, Greg W Albers¹, and Greg Zaharchuk¹

¹Stanford University, Stanford, CA, United States, ²Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany, ³University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, United States, ⁴Swedish Medical Center, Seattle, WA, United States, ⁵Eden Medical Center, Castro Valley, CA, United States

During acute stroke, perfusion of the ischemic penumbra might be sustained by both collaterals and elevated systemic blood pressure. Arterial Spin Labeling (ASL) is an MR imaging tool to quantify Cerebral Blood Flow (CBF) non-invasively. We focused on the non-affected brain hemisphere and utilized this contralateral CBF (cCBF) as an imaging biomarker for late neurological outcome prediction. Stroke patients were dichotomized by the median cCBF into high (>39 mL/100g/min) and low (<39 mL/100g/min) cCBF. Our analysis revealed that high cCBF predicts good neurological outcome at day 90 after stroke.

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