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Abstract #4840

Quantitative Cerebral Blood Flow Measured with Arterial Spin Labeling MRI in the Unaffected Contralateral Brain Hemisphere Predicts Outcome in Acute Ischemic Stroke

Thoralf Thamm1,2, Jia Guo1, Jarrett Rosenberg1, Tie Liang1, Michael P Marks1, Soren Christensen1, Huy M Do1, Stephanie M Kemp1, Emily A Ryan1, Tudor G Jovin3, Bart P Keogh4, Jenny Chen5, Maarten G Lansberg1, Greg W Albers1, and Greg Zaharchuk1

1Stanford University, Stanford, CA, United States, 2Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany, 3University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, United States, 4Swedish Medical Center, Seattle, WA, United States, 5Eden Medical Center, Castro Valley, CA, United States

During acute stroke, perfusion of the ischemic penumbra might be sustained by both collaterals and elevated systemic blood pressure. Arterial Spin Labeling (ASL) is an MR imaging tool to quantify Cerebral Blood Flow (CBF) non-invasively. We focused on the non-affected brain hemisphere and utilized this contralateral CBF (cCBF) as an imaging biomarker for late neurological outcome prediction. Stroke patients were dichotomized by the median cCBF into high (>39 mL/100g/min) and low (<39 mL/100g/min) cCBF. Our analysis revealed that high cCBF predicts good neurological outcome at day 90 after stroke.

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