Abstract #4843

MRI-derived Oxygen Metabolism and Neovascularization Characterization for Grading and IDH Gene Mutation Detection of Gliomas

Andreas Stadlbauer^1,2, Max Zimmermann¹, Arnd Dörfler³, Stefan Oberndorfer⁴, Michael Buchfelder¹, Gertraud Heinz², and Karl Rössler¹

¹Department of Neurosurgery, University of Erlangen-Nürnberg, Erlangen, Germany, ²Institute of Medical Radiology, University Clinic of St. Pölten, St. Pölten, Austria, ³Department of Neuroradiology, University of Erlangen-Nürnberg, Erlangen, Germany, ⁴Department of Neurology, University Clinic of St. Pölten, St. Pölten, Austria

The purpose was to explore the diagnostic performance of combined physiological MRI of oxygen metabolism and neovascularization for glioma grading and characterization of isocitrate-dehydrogenase-1 (IDH1) gene mutation status. 83 patients with glioma WHO°II-IV were examined using vascular architecture mapping (VAM) and multiparametric quantitative BOLD (mp-qBOLD). Neovascularization correlated with increasing WHO° and microvessel type indicator (MTI) had the best diagnostic performance (AUC=0.782) for differentiation between glioma WHO°III and IV. IDH1-mutation was associated with significantly decreased cerebral metabolic rate of oxygen (CMRO₂; P=0.037) in glioma WHO°II and significantly increased (P=0.013) MTI in glioma WHO°III, resulting in best diagnostic performance for IDH1-mutation detection.

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