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Abstract #4843

MRI-derived Oxygen Metabolism and Neovascularization Characterization for Grading and IDH Gene Mutation Detection of Gliomas

Andreas Stadlbauer1,2, Max Zimmermann1, Arnd Dörfler3, Stefan Oberndorfer4, Michael Buchfelder1, Gertraud Heinz2, and Karl Rössler1

1Department of Neurosurgery, University of Erlangen-Nürnberg, Erlangen, Germany, 2Institute of Medical Radiology, University Clinic of St. Pölten, St. Pölten, Austria, 3Department of Neuroradiology, University of Erlangen-Nürnberg, Erlangen, Germany, 4Department of Neurology, University Clinic of St. Pölten, St. Pölten, Austria

The purpose was to explore the diagnostic performance of combined physiological MRI of oxygen metabolism and neovascularization for glioma grading and characterization of isocitrate-dehydrogenase-1 (IDH1) gene mutation status. 83 patients with glioma WHO°II-IV were examined using vascular architecture mapping (VAM) and multiparametric quantitative BOLD (mp-qBOLD). Neovascularization correlated with increasing WHO° and microvessel type indicator (MTI) had the best diagnostic performance (AUC=0.782) for differentiation between glioma WHO°III and IV. IDH1-mutation was associated with significantly decreased cerebral metabolic rate of oxygen (CMRO2; P=0.037) in glioma WHO°II and significantly increased (P=0.013) MTI in glioma WHO°III, resulting in best diagnostic performance for IDH1-mutation detection.

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