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Abstract #4844

Vascular Hysteresis Loops and Vascular Architecture Mapping in Patients with Glioblastoma treated with Antiangiogenic Therapy

Andreas Stadlbauer1,2, Max Zimmermann1, Stefan Oberndorfer3, Arnd Dörfler4, Michael Buchfelder1, Gertraud Heinz2, and Karl Rössler1

1Department of Neurosurgery, University of Erlangen-Nürnberg, Erlangen, Germany, 2Institute of Medical Radiology, University Clinic of St. Pölten, St. Pölten, Austria, 3Department of Neurology, University Clinic of St. Pölten, St. Pölten, Austria, 4Department of Neuroradiology, University of Erlangen-Nürnberg, Erlangen, Germany

Glioblastoma are among the most vascularized of all solid tumors and attractive targets for antiangiogenic therapies. Antiangiogenic therapy response assessment in glioblastoma is challenging due to decreased vessel permeability and diminished contrast agent extravasation. Here, we investigated the variability of vascular hysteresis loop (VHL) shapes and the spatial heterogeneity of neovascularization using vascular architecture mapping (VAM) in patients with recurrent glioblastoma during bevacizumab mono-therapy. Responding, non-responding, progressive, and remote-progressive tumor areas were observed. Analysis of VHLs in combination with VAM biomarkers may lead to a new perspective on investigating the spatial heterogeneity of neovascularization in glioblastoma during antiangiogenic therapy.

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