Abstract #4849

Autopsy analysis of the overlap of radiomic profiles associated with poor overall survival and predictive maps of tumor cellularity in glioblastoma patients

Sarah L Hurrell¹, Sean McGarry², Elizabeth Cochran³, Jennifer Connelly⁴, Scott Rand¹, Wade Mueller⁵, and Peter S LaViolette¹

¹Radiology, The Medical College of Wisconsin, Milwaukee, WI, United States, ²The Medical College of Wisconsin, Milwaukee, WI, United States, ³Pathology, The Medical College of Wisconsin, Milwaukee, WI, United States, ⁴Neurology, The Medical College of Wisconsin, Milwaukee, WI, United States, ⁵Neurosurgery, The Medical College of Wisconsin, Milwaukee, WI, United States

Multiparametric MRI radiomic profiles (RPs) of de novo glioblastoma (GBM) brain tumors have been shown to predict patient prognosis prior to treatment. This study compares prognostic RPs to predictive maps of tumor cellularity derived from radiological-pathological (rad-path) correlation to determine the convergence of both imaging biomarkers. We find that RPs associated with poor prognosis co-localize with high cellularity, both predicted and pathologically confirmed in 6 patients assessed at autopsy.

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