Abstract #4850

Amide proton transfer-weighted imaging of glioblastoma and metastatic brain tumor: histogram analysis in enhancing tumors and peritumoral regions

Kiyohisa Kamimura¹, Masanori Nakajo¹, Tomohide Yoneyama¹, Hirofumi Hirano², Takashi Iwanaga³, Yuta Akamine⁴, Jochen Keupp⁵, and Takashi Yoshiura¹

¹Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, ²Neurosurgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, ³Clinical engineering department radiation section, department radiation section, Kagoshima, Japan, ⁴Philips Japan, Tokyo, Japan, ⁵Philips GmbH Innovative Technologies Research Laboratories, Aachen, Germany

To determine whether amide proton transfer-weighted imaging (APTWi) is useful for distinguishing glioblastomas (GBMs) from metastatic brain tumors (Mets), we compared APT-related signal intensity (APTSI) between the two tumor types in the areas of enhancing tumor and peritumoral high signal intensity areas (PHAs) using histogram analysis. In the enhancing tumor, the mean and 90,75,50,25 and 10 percentiles of APTSI histogram were significantly higher in GBMs than in Mets, whereas no APTSI histogram parameters in PHA showed significant difference between GBMs and Mets. APTSI in the areas of enhancing tumor, not in PHA is useful for differentiation between GBMs and Mets.

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