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Abstract #4852

High-resolution Deuterium MR Spectroscopic Imaging of the Warburg Effect in Brain Tumor

Ming Lu1, Xiao-Hong Zhu1, Yi Zhang1, Walter Low2, and Wei Chen1

1Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States, 2Neurosurgery Department, University of Minnesota, Minneapolis, MN, United States

The best-known metabolic abnormality in brain cancer is the Warburg effect, which shifts the fuel consumption from oxidation towards glycolysis. Recently, we developed a novel in vivo Deuterium (2H) MR spectroscopic imaging (DMRSI) approach for simultaneously assessing brain glycolysis and oxidation at 16.4 T. In this study, we aimed to image the Warburg effect in a rat model with gliosarcoma using DMRSI with improved resolution. High-resolution quantitative image using the ratio of [lactate] to [glutamate/glutamine] showed a huge contrast between brain tumor and intact tissue and promise to study the decoupling relationship between glycolysis and oxidation in tumor.

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