Meeting Banner
Abstract #4853

Edge Contrast of the FLAIR Hyperintense Region Predicts Survival in Patients with High Grade Gliomas Following Treatment with Bevacizumab

Naeim Bahrami1, David Piccioni1, Roshan Karunamuni1, Nate White1, Yu-Hsuan Chang1, Tyler Seibert1, Rachel Delfanti1, Jona jhattangadi-gluth1, Nikdokht Farid1, Anders M Dale1, and Carrie McDonald1

1University of California, San Diego, San Diego, CA, United States

Treatment with bevacizumab is standard of care for recurrent high grade gliomas (HGGs) and the level of border distinctness is a major parameter to monitor the therapy. Previously, the level of border distinctness was defined qualitative. In this study, we calculated the distinctness of the fluid-attenuated inversion recovery (FLAIR) hyperintense border—edge contrast (EC)—and showed it improves the evaluation of response to bevacizumab in patients with HGG. We showed that after bevacizumab, lower EC of the FLAIR hyperintense region was associated with poorer survival among HGG patients. We developed a quantitative parameter to characterize the border of the tumor.

This abstract and the presentation materials are available to members only; a login is required.

Join Here