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Abstract #4854

True-Diffusion Coefficient Retracted from Intra-Voxel Incoherent Motion (IVIM) Can Stratify Biopsy-Approved Infiltrative Edema from Normal Tissue and Active Tumor in Diffuse Brain Gliomas

Anahita Fathi Kazerooni1, Nima Gilani1, Mahnaz Nabil2, Mehdi Zeinalizadeh3, Kavous Firouznia4, Farid Azmoudeh-Ardalan5, Mohammad Peikari6, Mohammadreza Alviri1, Mehrdad Hadavand1, and Hamidreza Saligheh Rad1

1Quantitative MR Imaging and Spectroscopy Group, Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of), 2Department of Statistics, Faculty of Mathematical Science, University of Guilan, Rasht, Iran (Islamic Republic of), 3Department of Neurological Surgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of), 4Medical Imaging Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of), 5Department of Pathology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of), 6Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada

Infiltration of tumorous cells in the normal brain parenchyma is an intrinsic characteristic of diffuse gliomas and is a determinant factor in tumor recurrence, transformation into malignant form, and poor prognosis. The objective of this study was to investigate the role of intra-voxel incoherent motion (IVIM) imaging in characterizing tumor infiltration through localized biopsies. Histopathologically-approved regions of active tumor, infiltrative glioma (edema), and normal tissues were accurately discriminated by true (perfusion-free) diffusion coefficient (D).

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