Abstract #4865

23Na MRI at 7 Tesla for Early Response Assessment in Patients with Glioblastoma and Skull Base Meningioma

Sebastian Regnery^1,2, Daniel Paech³, Heiz-Peter Schlemmer³, Mark E. Ladd⁴, Armin M. Nagel^4,5, Stefan Rieken^1,2, Jürgen Debus^1,2, Sebastian Adeberg^1,2, and Nicolas G.R. Behl⁴

¹Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany, ²Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ³Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁴Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁵Institute of Radiology, University Hospital Erlangen, Erlangen, Germany

Radiotherapy is a cornerstone in the treatment of glioblastoma and skull base meningioma. Here, the first results of a prospective longitudinal study employing 23Na MRI for the response evaluation of glioblastoma and skull base meningioma patients during radiotherapy are presented. The study results show that radiation treatment of glioblastoma leads to considerable changes in sodium concentrations within the tumor and the surrounding edema that are dependent on treatment response.

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