Meeting Banner
Abstract #4868

Temporal evaluation of acute myocardial ischemia/reperfusion injury in rats using 7.0T magnetic resonance imaging and APT102 therapeutic effect

Ziqian Xu1, Jie Zheng2, and Fabao Gao1

1West China Hospital, Sichuan University, Chengdu, China, 2Washington University School of Medicine, St. Louis, MO, United States

Intramyocardial hemorrhage(IMH) and microvascualr obstruction(MVO) were the serious injuries in the early myocardial infarction reperfusion period, which were independent predictors of larger infarct size, lower systolic function and the worse prognosis at follow-up. APT102 as a synthetic apyrase of the hunman nucleoside triphosphate diphosphohydrolase-3(CD39L3) can exhibit ADPase activity, prevent thrombotic reocclusion and decrease infarct size without an increased bleeding risk. The purpose of this study was to continuously detect myocardial ischemia/reperfusion injury and APT102 effect in rats by 7.0T MRI.

This abstract and the presentation materials are available to members only; a login is required.

Join Here