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Abstract #4897

Self-gated respiratory-resolved 5D Flow MRI using the 3D spiral phyllotaxis trajectory

Monica Sigovan1, Gastao Cruz2, Torben Schneider3, Juan Felipe Perez-Juste Abascal1, Cyril Mory1, Guruprasad Krishnamoorty4, Rene Botnar2, Philippe Douek1,5, Claudia Prieto2, and Loic Boussel1,5

1CNRS, University of Lyon, CREATIS Laboratory, Lyon, France, 2School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom, 3Philips Healthcare, Guildford, United Kingdom, 4MR Clinical Science, Philips Healthcare, Best, Netherlands, 5Department of Interventional Radiology and Cardio-vascular and Thoracic Diagnostic Imaging, Hospices Civils de Lyon, Lyon, France

Clinical diagnosis based on thoracic blood flow using three-dimensional cardiac-resolved (4D) phase contrast PC-MRI is limited by long acquisition times, due to the need of respiratory gating. In addition, gating does not provide potentially important physiological information, the variation of flow within the respiratory cycle. To address these challenges we developed a 5D (4D respiratory-resolved) PC-MRI sequence combining 3D radial k-space sampling, respiratory self-gating, and compressed sensing reconstruction. Our preliminary results demonstrate respiratory related changes in blood flow in healthy subjects. The proposed method may potentially refine diagnosis in congenital heart disease by assessing the respiratory related blood flow variations.

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