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Abstract #4903

Propagation of Metaplastic Adipose Tissue Throughout the Scar of Hemorrhagic Myocardial Infarct is an Iron-Dependent Process: Cardiac MRI Study with Histological Insights

Ivan Cokic1, Guan Wang1, Xingmin Guan1, Hsin-Jung Yang1, Richard LQ Tang1, Diego Hernando2, Scott B Reeder2, and Rohan Dharmakumar1

1Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2University of Wisconsin, Madison, WI, United States

Lipomatous metaplasia (LM) of myocardial infarctions (MI) is typically observed in the peripheral zone of chronic MI and has been linked to major adverse clinical outcomes. To date, the mechanisms driving LM of MI remain unknown. A common feature of many disease processes associated with pathological fat accumulation is the iron-induced foam cell formation. Growing body of evidence now shows that iron deposits within hemorrhagic MI drive the prolonged recruitment of phagocytes into the infarcted territory. Herein, we investigated the spatial distribution and temporal accumulation of fatty infiltration in hemorrhagic MIs.

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