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Abstract #4915

Pulsatility and velocity in cerebral penetrating arteries in patients with carotid occlusive disease with 7T phase contrast: preliminary results

Tine Arts1, Laurien Onkenhout2, Jeroen Siero1, Jaco Zwanenburg1, and Geert Jan Biessels2

1Radiology, UMC Utrecht, Utrecht, Netherlands, 2Neurology, UMC Utrecht, Utrecht, Netherlands

The direct contribution of hemodynamics to the development and progression of vascular cognitive impairment (VCI) is relatively unexplored due to technical challenges concerning the assessment of hemodynamic properties of small vessels. This ongoing study explores changes of hemodynamics by measuring the velocity and pulsatility of perforating arteries in patients with internal carotid artery disease and healthy controls. The preliminary results indicate that high resolution velocity and pulsatility measurements in patients are challenging, particularly due to motion related artefacts. Thus, future research will evaluate user independent analysis to reduce the influence of artifacts and assess test-retest agreement by repeated scanning.

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