Physiological parameters derived from quantitative flow MRI can potentially improve characterization of a large spectrum of vascular diseases if routinely used in a clinical setting. However, current barriers limit the use of quantitative flow MRI in a clinical setting, partially due to a lack of calibration tests, and concerns regarding accuracy and reproducibility. In this study we investigate the potential induced bias of flow measurements in a cranial 4D flow MRI acquisition due to signal magnitude heterogeneity, and the implications for comparing protocols with differing flip angle or contrast agent usage.
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