Abstract #4921

Blood Brain Barrier Water Permeability in Non-Enhancing Multiple Sclerosis Lesion with Intrinsic Diffusivity Encoding of Arterial Labeled Spins (IDEALS)

Kenneth T Wengler¹, Jason Ha², Patricia Coyle³, Mark Schweitzer⁴, Tim Q Duong⁴, and Xiang He⁴

¹Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, ²Biology, Stony Brook University, Stony Brook, NY, United States, ³Neurology, Stony Brook University Hospital, Stony Brook, NY, United States, ⁴Radiology, Stony Brook University Hospital, Stony Brook, NY, United States

Persistent endothelial abnormalities and blood-brain barrier (BBB) disruption may play an important role in MS lesion formation and progression. In MS, BBB dysfunction occurs not only in active lesions with contrast-enhancement, but also in inactive (chronic) lesions and normal appearing white matter. In this study a novel method to map whole-brain BBB water permeability (IDEALS) was used to measure in non-enhancing MS lesions of 11 relapse-remitting MS patients. Although the permeability for MRI contrast in non-enhancing MS lesions is several orders of magnitude lower than that of enhancing MS lesions, our study demonstrated a robust reduction of lesion water permeability.

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