Meeting Banner
Abstract #4929

Age-related shift of cerebral venous outflow pathway detected by BOLD signal-based blood flow tracking

Toshihiko Aso1,2, Shinnichi Urayama2, Tsukasa Ueno1, Naoya Oishi2, Yukako Nakagami1, Toshiya Murai1, and Hidenao Fukuyama3

1Department of Psychiatry, Kyoto University Graduate School of Medicine, Kyoto, Japan, 2Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan, 3Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Kyoto, Japan

A novel blood tracking technique based on BOLD MRI signal was applied to two age groups of healthy subjects (n=81) to investigate age-related alterations in cerebral circulation. By mapping the phase of low-frequency component and between-subject regression analysis on this “BOLD lag map”, linear extension of venous drainage times with age was found in the deep venous system draining the periventricular region. Interestingly, age-related shortening of washout time was observed in the superficial system involving the major sinuses. This dissociation of deep and superficial venous systems may reflect focal inefficiency in the deep system as part of normal aging processes.

This abstract and the presentation materials are available to members only; a login is required.

Join Here