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Abstract #4930

Cerebral Blood Flow, Intracranial Volumes and Cognitive Status in Type-2 Diabetes Mellitus

Leanne Hunt1, Dinesh Selvarajah1, Solomon Tesfaye2, and Iain D Wilkinson1

1Academic Units of Radiology & Diabetes, University of Sheffield, Sheffield, United Kingdom, 2Diabetes, Sheffield Teaching Hospitals, Sheffield, United Kingdom

This study quantitates regional brain volumes and arterial cerebral perfusion characteristics (ASL) in patients with Type-2 Diabetes Mellitus (T2DM) who have Mild Cognitive Impairment, in patients with T2DM who have normal cognitive status and in non-diabetic healthy volunteers. Mean group differences were identified in both grey matter volume and cerebral blood flow in regions that include the medial temporal lobes. These findings may further our understanding of the mechanisms that lead to an increased risk of the development of cognitive impairment associated with diabetes.

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