This study quantitates regional brain volumes and arterial cerebral perfusion characteristics (ASL) in patients with Type-2 Diabetes Mellitus (T2DM) who have Mild Cognitive Impairment, in patients with T2DM who have normal cognitive status and in non-diabetic healthy volunteers. Mean group differences were identified in both grey matter volume and cerebral blood flow in regions that include the medial temporal lobes. These findings may further our understanding of the mechanisms that lead to an increased risk of the development of cognitive impairment associated with diabetes.
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