Concurrent cardiac and neurovascular (4D flow) MR imaging were used to quantify cardiac and cerebral hemodynamics in 30 healthy adults to determine the relationship to brain volumetric measures of regions considered vulnerable in aging. Cardiac index (p=0.001); ascending aorta (p=0.003) total cerebral blood flow (p=0.001) and flow for left internal carotid (p<0.001), basilar (p=0.04), and right anterior cerebral (p=0.03) arteries were significantly lower in midlife compared to younger adults. Lower cardiac index, total cerebral blood flow and left internal carotid flow were correlated with reduced gray matter, superior frontal cortical thinning and volume loss in putamen.
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