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Abstract #4932

Altered cerebral blood flow before and after 4-weeks of neurostimulation in patients with episodic migraine

Lars Michels1, Jessica Aschmann2, Franz Riederer1, Andreas Gantenbein1,3, Roger Luechinger4, Spyros Kolllias1, and Peter Sandor3

1University Hospital Zurich, Zurich, Switzerland, 2Unversity of Zurich, Zurich, Switzerland, 3Rehaclinic Bad Zurzach, Zurzach, Switzerland, 4Swiss Federal Institute of Technology and the University of Zurich, Zurich, Switzerland

Cerebral blood flow is altered in migraineurs but it is unknown if this can be changed by repetitive neurostimulation, leading to less migraine attacks. In a double blind and sham-controlled study, we used arterial spin labeling MRI and transcranial direct current stimulation (tDCS) to address this question. Four weeks of real tDCS diminished initial hyperperfusion in patients with episodic migraine in pain processing brain regions (p < 0.001). In addition, less migraine attacks occurred after real tDCS compared to baseline (p < 0.05). Our results indicate a regulating effect of tDCS on cerebral blood flow and clinical outcome in migraineurs.

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