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Abstract #4933

Quantifying brain oxygen extraction fraction: correlation between a global venous susceptibility method and calibrated fMRI mapping method.

Hannah L Chandler1, Michael Germuska1, Thomas W Okell2, Ana E Rodriguez-Soto3, Erin K Englund3, Rachael C Stickland1, Catherine Foster1, Jessica Steventon 4, Fabrizio Fasano5, Kevin Murphy6, Valentina Tomassini4, Felix W Wehrli3, and Richard G Wise1

1CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom, 2Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, United Kingdom, 3Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 4School of Medicine, Cardiff University, Cardiff, United Kingdom, 5Siemens Healthcare Ltd, Camberley, United Kingdom, 6School of Physics and Astronomy, Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, United Kingdom

Measuring oxygen extraction fraction (OEF) may prove a useful clinical tool for assessing brain oxygen consumption. Dual-calibrated fMRI is used to map voxel-wise OEF across grey-matter and requires respiratory challenge (hypercapnia and hyperoxia). However, this method presents challenges to clinical implementation. Conversely, OxFlow provides a global estimate of OEF, has a shorter acquisition time and does not require respiratory challenge. Here we examine the relationship between both approaches for measuring OEF, revealing a significant association between methods. While further investigation is required, OxFlow may offer additional clinical utility for measuring cerebral oxygen consumption.

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