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Abstract #4938

Effects of Track Length on White Matter Alterations in Mild Traumatic Brain Injury

Sourajit Mitra Mustafi1, Jaroslaw Harezlak2, Joaquin Goni3, Laura A Flashman4, Thomas W McAllister5, and Yu-Chien Wu1

1Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, 2Department of Epidemiology and Biostatistics, Indiana University, School of Public Health, Bloomington, IN, United States, 3College of Engineering, Purdue University, West Lafayette, IN, United States, 4Department of Psychiatry, Dartmouth-Hitchcock Medical Center and Geisel School of Medicine, Hanover, NH, United States, 5Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, United States

In the present study, we performed streamline tractography to characterize effects of track length on white-matter microstructural alterations after mild traumatic brain injury. Streamline length and counts were studied in involved white-matter fiber tracts that were found to have decreased axonal density at some points along the tracts using voxel-based analyses. The results suggested that long fibers in the brains of individuals who sustained mild traumatic brain injury are more vulnerable to the injury.

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