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Abstract #4939

Regional fractional anisotropy and processing speed in diffuse traumatic brain injury: An exploratory analysis using a linear regression panel model

Sindhuja T Govindarajan1, David J Ouellette1, Junghoon Kim2, and Tim Q Duong3

1Stony Brook University, Stony Brook, NY, United States, 2Department of Molecular, Cellular, and Biomedical Sciences, The City College of New York School of Medicine, New York, NY, United States, 3Stony Brook University School of Medicine, Stony Brook, NY, United States

Recently, Ware and colleagues1 showed that FA-derived damage assessment in WM regions can accurately classify subjects with processing speed impairment in moderate to severe diffuse TBI at 3 months post-injury. Using a subset of the same cohort who completed follow-up DTI scans at 6 and 12 months post-injury, the goals of this study were 1) to investigate if regional FA remains associated with processing speed in a dataset including all time points and 2) to conduct an exploratory analysis to identify a subset of regions that can best explain such association. Four regions were identified that explained most variance in processing speed.

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