Abstract #4942

Evaluating Microstructural Integrity of Cortical and Deep Gray Matter over a Season of High School Football Using Diffusion Kurtosis Imaging and Quantitative Susceptibility Mapping

Nan-Jie Gong^1,2, Samuel Kuzminski³, Michael Clark⁴, Melissa Fraser⁴, Mark Sundman⁵, Kevin Guskiewicz⁴, Jeffrey R Petrella², and Chunlei Liu^1,2

¹University of California Berkeley, Berkeley, CA, United States, ²Duke University School of Medicine, Durham, NC, United States, ³University of Oklahoma, Norman, OK, United States, ⁴University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, United States, ⁵University of Arizona, Tucson, AZ, United States

Over the course of a single high school football season, QSM showed no evidence of microhemorrhage or iron-related changes; however, we observed significant microstructural alterations, as reflected by DKI metrics, in cortical and deep gray matter over the course of a single high school football season. These microstructural changes correlated with the frequency of head impacts, suggesting that DKI imaging of cortical and deep gray matter may yield valuable biomarkers for tracking subclinical traumatic brain injury in contact-sport athletes.

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