Abstract #4943

Exploring the effects of concussion history on quantitative estimation of temporal delays and cerebrovascular reactivity: A novel approach combining hypercapnia and hyperoxia in collegiate football players

ALLEN A. CHAMPAGNE¹, NICOLE S. COVERDALE¹, ALEX A. BHOGAL², and DOUGLAS J. COOK^1,3

¹Centre for Neuroscience studies at Queen's University, Kingston, ON, Canada, ²Department of Radiology at the University Medical Center Utrecht, Utrecht, Netherlands, ³Department of Surgery at Queen's University, Kingston, ON, Canada

Recent evidence suggests that concussion history may be associated with long-term structural and functional changes in the brain. However, little is known about the effects of head injury on vascular reactivity. In this study, we combined hypercapnic and hyperoxic respiratory manipulations to explore the effects of concussion history on hemodynamic latencies and tissue cerebrovascular reactivity (CVR) in football players. We found that, although tissue CVR was not different between the groups (P>0.05), time delays to hypercapnia were shorter in subjects with a history of concussion (P<0.05), which may suggest some compensatory mechanism in the vasculature that persists beyond clinical recovery.

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